Peptides and Longevity: What We Know So Far and what is the craze all about?

Molecular structure illustration of peptides, highlighting their potential role in promoting longevity and health benefits.

Peptides are small proteins that act like messengers in the body. Some help regulate metabolism, immune function, and even aging. Scientists are now studying how certain peptides might help extend lifespan and improve health in old age.

Key Types of Peptides Studied for Longevity

1. Mitochondrial-Derived Peptides (MDPs)-

• Found in mitochondria (the cell’s powerhouses).

• Examples: Humanin, MOTS-c, SHLPs.

• Help cells resist stress, improve energy use, and reduce inflammation.

2. Thymic and Pineal Peptides-

• Made in the thymus and pineal glands.

• Examples: Thymalin, Epithalamin, Epitalon.

• Improve immunity, regulate sleep hormones, and may extend lifespan (shown in animal and small human studies).

3. Food- and Marine-Derived Peptides-

• Found in milk, fish, turtles, and plants.

• Support antioxidant defenses and healthy aging in worms and rodents.

4. Synthetic Short Peptides-

• Lab-made versions designed to target specific tissues.

• Show promise in preclinical studies.

How Peptides Work

Peptides support longevity by:

• Improving mitochondrial function (energy production).

• Reducing oxidative stress and inflammation.

• Boosting antioxidant enzymes.

• Supporting key aging pathways like AMPK, mTOR, and insulin/IGF-1.

• Enhancing autophagy (cell cleanup) and proteostasis (protein balance).

Animal Studies: Promising Results

• Some peptides have extended animal lifespan by 20–40%.

• They also delay age-related diseases and improve stress resistance.

• For example, Epitalon restored sleep hormone rhythms and increased lifespan in rodents.

• Marine peptides helped worms and flies live longer and move better with age.

• Toxicity was low in these studies.

What Do Human Studies Show?

• Thymic and pineal peptides have the most human research.

• In one 6–8 year study, older adults had lower death rates and fewer illnesses after using Thymalin and Epithalamin.

• Food-derived peptides (e.g., from milk or fish) showed benefits for muscle health and inflammation, but not direct longevity effects.

• MDPs like humanin and MOTS-c look promising for preventing age-related diseases, but large human trials are still missing.

Are Peptides Safe?

• So far, they appear to be safe in short- to medium-term studies, with few reported side effects.

• Long-term safety and potential immune reactions still need more research.

How Do Peptides Compare to Other Anti-Aging Therapies?

Peptide_AntiAging_Therapy_Comparison.pdf

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How Are Peptides Taken and Monitored?

• Most need to be injected, not taken by mouth.

• Dosing isn’t standardized—many protocols are based on older Russian or European studies.

• There’s no agreed-upon way to monitor effectiveness or long-term safety.

Who Might Benefit?

• People over 60, especially those with weak immune systems or hormone imbalances, may benefit most.

• Not recommended for younger people or those with cancer, autoimmune disease, or many health issues.

Regulatory and Real-World Use

• Peptides are not approved by major health agencies (e.g., FDA) for anti-aging.

• Still, they are used off-label in clinics or sold as supplements—often without strict quality control.

• Growth hormone use for aging is illegal in the U.S. and carries serious risks.

What’s Next?

• New peptide designs using AI and synthetic biology could make them more stable and effective.

• Better delivery systems (like nanoparticles or exosomes) are being developed to avoid frequent injections.

• Marine peptides are a growing area of research due to their unique properties.

Bottom Line

Peptides are one of the most exciting areas in longevity science—but most of the evidence comes from animals, not people. A few types (like Thymalin and Epithalamin) show promise in older adults, but more research is needed to know who they help, how to use them safely, and what risks they carry long term.

Our take-

We are closely monitoring this space and will implement when we have enough safety and efficacy data.

References

1. The Mitochondrial Derived Peptide Humanin Is a Regulator of Lifespan and Healthspan. Yen K, Mehta HH, Kim SJ, et al. Aging. 2020;12(12):11185-11199. doi:10.18632/aging.103534.

2. Mitochondria-Derived Peptides in Healthy Ageing and Therapy of Age-Related Diseases. Dabravolski SA. Advances in Protein Chemistry and Structural Biology. 2023;136:197-215. doi:10.1016/bs.apcsb.2023.02.015.

3. Mitochondrial-Derived Peptides in Aging and Age-Related Diseases. Kim SJ, Miller B, Kumagai H, et al. GeroScience. 2021;43(3):1113-1121. doi:10.1007/s11357-020-00262-5.

4. Mitochondria-Derived Peptides in Aging and Healthspan. Miller B, Kim SJ, Kumagai H, Yen K, Cohen P. The Journal of Clinical Investigation. 2022;132(9):e158449. doi:10.1172/JCI158449.

5. Peptides and Ageing. Khavinson VKh. Neuro Endocrinology Letters. 2002;23 Suppl 3:11-144.

6. Peptide Bioregulation of Aging: Results and Prospects. Anisimov VN, Khavinson VKh. Biogerontology. 2010;11(2):139-49. doi:10.1007/s10522-009-9249-8.

7. Exogenous Bioactive Peptides Have a Potential Therapeutic Role in Delaying Aging in Rodent Models. Wang J, Wu Y, Chen Z, et al. International Journal of Molecular Sciences. 2022;23(3):1421. doi:10.3390/ijms23031421.

8. Marine Peptides as Potential Anti-Aging Agents: Preparation, Characterization, Mechanisms of Action, and Future Perspectives. Yao W, Zhang Y, Zhang G. Food Chemistry. 2024;460(Pt 1):140413. doi:10.1016/j.foodchem.2024.140413.

9. Antiaging Potential of Peptides From Underused Marine Bioresources. Xia E, Zhu X, Gao X, Ni J, Guo H. Marine Drugs. 2021;19(9):513. doi:10.3390/md19090513.

10. Stress Resistance and Lifespan Extension of Caenorhabditis Elegans Enhanced by Peptides From Mussel (Mytilus Edulis) Protein Hydrolyzate. Zhou Y, Xu Q, Zhou X, Song S, Zhu B. Food & Function. 2018;9(6):3313-3320. doi:10.1039/c8fo00021b.

11. The Novel Dipeptide Tyr-Ala (TA) Significantly Enhances the Lifespan and Healthspan of Caenorhabditis Elegans. Zhang Z, Zhao Y, Wang X, et al. Food & Function. 2016;7(4):1975-84. doi:10.1039/c5fo01302j.

12. Soft-Shelled Turtle Peptides Extend Lifespan and Healthspan in . Wang Q, Zhang J, Zhuang J, et al. Nutrients. 2022;14(24):5205. doi:10.3390/nu14245205.

13. Supplementation of Mussel Peptides Reduces Aging Phenotype, Lipid Deposition and Oxidative Stress in D-Galactose-Induce Aging Mice. Zhou Y, Xu Q, Dong Y, et al. The Journal of Nutrition, Health & Aging. 2017;21(10):1314-1320. doi:10.1007/s12603-016-0862-3.

14. Peptides of Pineal Gland and Thymus Prolong Human Life. Khavinson VKh, Morozov VG. Neuro Endocrinology Letters. 2003 Jun-Aug;24(3-4):233-40.

15. The Role of Peptides in Nutrition: Insights Into Metabolic, Musculoskeletal, and Behavioral Health: A Systematic Review. Zakir SK, Jawed B, Esposito JE, et al. International Journal of Molecular Sciences. 2025;26(13):6043. doi:10.3390/ijms26136043.

16. Mitochondrial Peptides Modulate Mitochondrial Function During Cellular Senescence. Kim SJ, Mehta HH, Wan J, et al. Aging. 2018;10(6):1239-1256. doi:10.18632/aging.101463.

17. Naturally Occurring Mitochondrial-Derived Peptides Are Age-Dependent Regulators of Apoptosis, Insulin Sensitivity, and Inflammatory Markers. Cobb LJ, Lee C, Xiao J, et al. Aging. 2016;8(4):796-809. doi:10.18632/aging.100943.

18. Targeting Aging Mechanisms: Pharmacological Perspectives. Moskalev A, Guvatova Z, Lopes IA, et al. Trends in Endocrinology and Metabolism: TEM. 2022;33(4):266-280. doi:10.1016/j.tem.2022.01.007.

19. Bioactive Peptides in the Management of Lifestyle-Related Diseases: Current Trends and Future Perspectives. Singh BP, Aluko RE, Hati S, Solanki D. Critical Reviews in Food Science and Nutrition. 2022;62(17):4593-4606. doi:10.1080/10408398.2021.1877109.

20. Bioactive Peptides in Preventative Healthcare: An Overview of Bioactivities and Suggested Methods to Assess Potential Applications. Hayes M. Current Pharmaceutical Design. 2021;27(11):1332-1341. doi:10.2174/1381612827666210125155048.

21. A Micronutrient Mixture With Collagen Peptides, Probiotics, Cannabidiol, and Diet May Reduce Aging, and Development and Progression of Age-Related Alzheimer's Disease, and Improve Its Treatment. Prasad KN. Mechanisms of Ageing and Development. 2023;210:111757. doi:10.1016/j.mad.2022.111757.

22. A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan. Mohammed I, Hollenberg MD, Ding H, Triggle CR. Frontiers in Endocrinology. 2021;12:718942. doi:10.3389/fendo.2021.718942.

23. The Use of Metformin to Increase the Human Healthspan. Piskovatska V, Storey KB, Vaiserman AM, Lushchak O. Advances in Experimental Medicine and Biology. 2020;1260:319-332. doi:10.1007/978-3-030-42667-5_13.

24. Targeting Ageing and Preventing Organ Degeneration With Metformin. Sunjaya AP, Sunjaya AF. Diabetes & Metabolism. 2021;47(1):101203. doi:10.1016/j.diabet.2020.09.009.

25. The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging. Zhang Y, Zhang J, Wang S. Ageing Research Reviews. 2021;70:101376. doi:10.1016/j.arr.2021.101376.

26. Blazing a Trail for the Clinical Use of Rapamycin as a geroprotecTOR. Konopka AR, Lamming DW. GeroScience. 2023;45(5):2769-2783. doi:10.1007/s11357-023-00935-x.

27. Rapalogs and mTOR Inhibitors as Anti-Aging Therapeutics. Lamming DW, Ye L, Sabatini DM, Baur JA. The Journal of Clinical Investigation. 2013;123(3):980-9. doi:10.1172/JCI64099.

28. Senolytic Drugs: From Discovery to Translation. Kirkland JL, Tchkonia T. Journal of Internal Medicine. 2020;288(5):518-536. doi:10.1111/joim.13141.

29. Cellular Senescence and Senolytics: The Path to the Clinic. Chaib S, Tchkonia T, Kirkland JL. Nature Medicine. 2022;28(8):1556-1568. doi:10.1038/s41591-022-01923-y.

30. Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span. Robbins PD, Jurk D, Khosla S, et al. Annual Review of Pharmacology and Toxicology. 2021;61:779-803. doi:10.1146/annurev-pharmtox-050120-105018.

31. Pharmacokinetics and Pharmacokinetic-Pharmacodynamic Correlations of Therapeutic Peptides. Diao L, Meibohm B. Clinical Pharmacokinetics. 2013;52(10):855-68. doi:10.1007/s40262-013-0079-0.

32. Translatability of Life-Extending Pharmacological Treatments Between Different Species. Burdusel D, Coman C, Ancuta DL, et al. Aging Cell. 2024;23(7):e14208. doi:10.1111/acel.14208.

33. Developing Criteria for Evaluation of Geroprotectors as a Key Stage Toward Translation to the Clinic. Moskalev A, Chernyagina E, Tsvetkov V, et al. Aging Cell. 2016;15(3):407-15. doi:10.1111/acel.12463.

34. Oral Peptide Delivery: Translational Challenges Due to Physiological Effects. Tyagi P, Pechenov S, Anand Subramony J. Journal of Controlled Release : Official Journal of the Controlled Release Society. 2018;287:167-176. doi:10.1016/j.jconrel.2018.08.032.

35. In Vivo Degradation Forms, Anti-Degradation Strategies, and Clinical Applications of Therapeutic Peptides in Non-Infectious Chronic Diseases. Tasdemiroglu Y, Gourdie RG, He JQ. European Journal of Pharmacology. 2022;932:175192. doi:10.1016/j.ejphar.2022.175192.

36. Translating the Science of Aging Into Therapeutic Interventions. Kirkland JL. Cold Spring Harbor Perspectives in Medicine. 2016;6(3):a025908. doi:10.1101/cshperspect.a025908.

37. Translating Advances From the Basic Biology of Aging Into Clinical Application. Kirkland JL. Experimental Gerontology. 2013;48(1):1-5. doi:10.1016/j.exger.2012.11.014.

38. Barriers to the Preclinical Development of Therapeutics That Target Aging Mechanisms. Burd CE, Gill MS, Niedernhofer LJ, et al. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2016;71(11):1388-1394. doi:10.1093/gerona/glw112.

39. Advancing Geroscience Research - A Scoping Review of Regulatory Environments for Gerotherapeutics. Muscedere J, Shorey CL, Duque G, et al. The Journal of Nutrition, Health & Aging. 2025;29(9):100637. doi:10.1016/j.jnha.2025.100637.

40. American Association of Clinical Endocrinologists and American College of Endocrinology Guidelines for Management of Growth Hormone Deficiency in Adults and Patients Transitioning From Pediatric to Adult Care. Yuen KCJ, Biller BMK, Radovick S, et al. Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2019;25(11):1191-1232. doi:10.4158/GL-2019-0405.

41. GH and Ageing: Pitfalls and New Insights. Bartke A, Darcy J. Best Practice & Research. Clinical Endocrinology & Metabolism. 2017;31(1):113-125. doi:10.1016/j.beem.2017.02.005.

42. Biomedical Applications of a Novel Class of High-Affinity Peptides. Saw PE, Xu X, Kim S, Jon S. Accounts of Chemical Research. 2021;54(18):3576-3592. doi:10.1021/acs.accounts.1c00239.

43. Strategies for Improving Peptide Stability and Delivery. Al Musaimi O, Lombardi L, Williams DR, Albericio F. Pharmaceuticals (Basel, Switzerland). 2022;15(10):1283. doi:10.3390/ph15101283.

44. From Precision Synthesis to Cross-Industry Applications: The Future of Emerging Peptide Technologies. Wang M, Xia H, Wang C, et al. Pharmacological Research. 2025;218:107839. doi:10.1016/j.phrs.2025.107839.

45. Unstructured Polypeptides as a Versatile Drug Delivery Technology. Ji Y, Liu D, Zhu H, et al. Acta Biomaterialia. 2023;164:74-93. doi:10.1016/j.actbio.2023.04.019.

46. Recent Advances in Half-Life Extension Strategies for Therapeutic Peptides and Proteins. Tan H, Su W, Zhang W, et al. Current Pharmaceutical Design. 2018;24(41):4932-4946. doi:10.2174/1381612825666190206105232.

47. The Industrial Design, Translation, and Development Strategies for Long-Acting Peptide Delivery. Yang B, Gomes Dos Santos A, Puri S, Bak A, Zhou L. Expert Opinion on Drug Delivery. 2022;19(10):1233-1245. doi:10.1080/17425247.2022.2098276.

48. Potential Active Marine Peptides as Anti-Aging Drugs or Drug Candidates. Yang H, Zhang Q, Zhang B, Zhao Y, Wang N. Marine Drugs. 2023;21(3):144. doi:10.3390/md21030144.

49. Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action. Akbarian M, Khani A, Eghbalpour S, Uversky VN. International Journal of Molecular Sciences. 2022;23(3):1445. doi:10.3390/ijms23031445.

50. Human Trials Exploring Anti-Aging Medicines. Guarente L, Sinclair DA, Kroemer G. Cell Metabolism. 2024;36(2):354-376. doi:10.1016/j.cmet.2023.12.007.

51. New Horizons in Life Extension, Healthspan Extension and Exceptional Longevity. Le Couteur DG, Barzilai N. Age and Ageing. 2022;51(8):afac156. doi:10.1093/ageing/afac156.

52. New Horizons: Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms. Tchkonia T, Palmer AK, Kirkland JL. The Journal of Clinical Endocrinology and Metabolism. 2021;106(3):e1481-e1487. doi:10.1210/clinem/dgaa728.

53. The Quest to Slow Ageing Through Drug Discovery. Partridge L, Fuentealba M, Kennedy BK. Nature Reviews. Drug Discovery. 2020;19(8):513-532. doi:10.1038/s41573-020-0067-7.

54. Immunomodulatory and Antiaging Mechanisms of Resveratrol, Rapamycin, and Metformin: Focus on mTOR and AMPK Signaling Networks. Sorrenti V, Benedetti F, Buriani A, et al. Pharmaceuticals (Basel, Switzerland). 2022;15(8):912. doi:10.3390/ph15080912.

55. Aging and Age-Related Diseases: From Mechanisms to Therapeutic Strategies. Li Z, Zhang Z, Ren Y, et al. Biogerontology. 2021;22(2):165-187. doi:10.1007/s10522-021-09910-5.

56. Pharmaceutical Intervention of Aging. Qian M, Liu B. Advances in Experimental Medicine and Biology. 2018;1086:235-254. doi:10.1007/978-981-13-1117-8_15.

57. Health Benefits of Anti-Aging Drugs. Piskovatska V, Strilbytska O, Koliada A, Vaiserman A, Lushchak O. Sub-Cellular Biochemistry. 2019;91:339-392. doi:10.1007/978-981-13-3681-2_13.

58. Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop. Espinoza SE, Khosla S, Baur JA, de Cabo R, Musi N. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2023;78(Suppl 1):53-60. doi:10.1093/gerona/glad034.

59. Bioactive Peptides: From Basic Research to Clinical Trials and Commercialization. Duffuler P, Bhullar KS, de Campos Zani SC, Wu J. Journal of Agricultural and Food Chemistry. 2022;70(12):3585-3595. doi:10.1021/acs.jafc.1c06289.